Synthesis of the Racemate and Both Enantiomers of Biologically Active 4-(2,6-Dimethylheptyl)Benzoic Acid and Their Effect on Cholesterol Accumulation in Aorta Cells

A chemical and enzymatic approach to the synthesis of ( S )- and ( R )-3-(4-methoxycarbonyl)phenyl-2- methyl-1-propanols, convenient intermediates for the synthesis of both enantiomers of 4-(2,6-dimethylheptyl) benzoic acid, was described. The biological activity of ( R )- and ( S )-isomers of the r...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2015-05, Vol.49 (2), p.73-77
Main Authors: Gamalevich, G. D., Vlasyuk, A. L., Serebryakov, É. P.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:A chemical and enzymatic approach to the synthesis of ( S )- and ( R )-3-(4-methoxycarbonyl)phenyl-2- methyl-1-propanols, convenient intermediates for the synthesis of both enantiomers of 4-(2,6-dimethylheptyl) benzoic acid, was described. The biological activity of ( R )- and ( S )-isomers of the racemic acid was studied. It was established that the ( S )-configuration of its antipode in the racemate decreased the cholesterol level in aorta cells.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-015-1224-x