Benzo[h]thiazolo[2,3-b]quinazolines by an efficient p-toluenesulfonic acid-catalyzed one-pot two-step tandem reaction

A highly efficient method has been developed for synthesis of 7,9-disubstituted-6,7-dihydro-5 H -benzo[ h ]thiazolo[2,3- b ]quinazolines via multicomponent one-pot two-step tandem reaction involving 1-tetralone, arylaldehydes, thiourea, and 4-chlorophenacyl bromide/(3-bromoacetyl)coumarin utilizing...

Full description

Saved in:
Bibliographic Details
Published in:Research on chemical intermediates 2016-03, Vol.42 (3), p.1699-1705
Main Authors: Sakram, B., Sonyanaik, B., Ashok, K., Rambabu, S., Johnmiya, S. K.
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Physical Chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A highly efficient method has been developed for synthesis of 7,9-disubstituted-6,7-dihydro-5 H -benzo[ h ]thiazolo[2,3- b ]quinazolines via multicomponent one-pot two-step tandem reaction involving 1-tetralone, arylaldehydes, thiourea, and 4-chlorophenacyl bromide/(3-bromoacetyl)coumarin utilizing p -toluenesulfonic acid as catalyst in glacial acetic acid under reflux conditions. Analytically pure products are formed with excellent yield and short reaction time. All the synthesized compounds were confirmed by their spectral and elemental analyses. Graphical abstract
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-015-2112-4