Debenzylation of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane

The debenzylation of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetra-cyclo[5.5.0.0 3,11 .0 5,9 ]dodecane by catalytic hydrogenolysis in a mixture of HCOOH with other RCOOH (R = Me, Et, Pr i ) is accompanied by the N -formylation of the liberated secondary amino groups. The alkaline hyd...

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Bibliographic Details
Published in:Russian chemical bulletin 2009-10, Vol.58 (10), p.2164-2168
Main Authors: Kalashnikov, A. I., Sysolyatin, S. V., Sakovich, G. V., Surmacheva, I. A., Surmachev, V. N., Lapina, Yu. T.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
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Summary:The debenzylation of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetra-cyclo[5.5.0.0 3,11 .0 5,9 ]dodecane by catalytic hydrogenolysis in a mixture of HCOOH with other RCOOH (R = Me, Et, Pr i ) is accompanied by the N -formylation of the liberated secondary amino groups. The alkaline hydrolysis of the obtained products makes it possible to remove the formyl groups with the retention of the acetyl groups.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-009-0295-9