Synthesis of cinnoline 1-oxides by the reaction of ortho-fluoronitrobenzenes with enediamines

Reaction of α-carbonylacetamidines existing in the enediamine tautomeric form with the substituted ortho -fluoronitrobenzene afforded products of the replacement of the fluorine by the α-C atom of amidine. The latter underwent cyclization into cinnoline 1-oxides on treatment with sodium hydride.

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Bibliographic Details
Published in:Russian chemical bulletin 2012-04, Vol.61 (4), p.877-880
Main Authors: Vypolzov, A. V., Dar’in, D. V., Lobanov, P. S.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
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Summary:Reaction of α-carbonylacetamidines existing in the enediamine tautomeric form with the substituted ortho -fluoronitrobenzene afforded products of the replacement of the fluorine by the α-C atom of amidine. The latter underwent cyclization into cinnoline 1-oxides on treatment with sodium hydride.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-012-0123-5