Solubility and hydrolytic stability of indomethacin in aqueous micellar solutions

The solubility of the indomethacin drug in aqueous micellar solutions of a series of dicationic surfactants was characterized by spectrophotometry. The use of these surfactants can significantly increase the indomethacin content in aqueous solutions without destruction of the drug. The increase in t...

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Bibliographic Details
Published in:Russian chemical bulletin 2015-09, Vol.64 (9), p.2232-2237
Main Authors: Yackevich, E. I., Mirgorodskaya, A. B., Zakharova, L. Ya, Sinyashin, O. G.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Inorganic Chemistry
Organic Chemistry
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Summary:The solubility of the indomethacin drug in aqueous micellar solutions of a series of dicationic surfactants was characterized by spectrophotometry. The use of these surfactants can significantly increase the indomethacin content in aqueous solutions without destruction of the drug. The increase in the solubility can be explained by the multifactorial mechanism of the influence of micelles involving the solubilization of the drug and its binding with surfactants due to electrostatic and specific interactions. The use of dicationic surfactants in alkaline solutions was shown to markedly accelerate the hydrolytic cleavage of indomethacin. The highest catalytic effect is observed for N , N ´-(hexane-1,6-diyl)bis(2-hydroxyethyl)(methyl)(cetyl)ammonium dibromide: a 1200-fold increase in the reaction rate of alkaline hydrolysis of the drug.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-015-1143-8