First episode psychosis with extrapyramidal signs prior to antipsychotic drug treatment

Extrapyramidal movement disorders are common in chronic schizophrenia, and may be an intrinsic feature of the illness as well as related to antipsychotic drug treatment. Similar dysfunctions at illness onset may have implications for outcome, and for under standing the mechanisms of illness. The obj...

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Bibliographic Details
Published in:Chinese science bulletin 2011-11, Vol.56 (32), p.3361-3371
Main Authors: Honer, William G., Lang, Donna J., Kopala, Lili C., Macewan, G. William, Smith, Geoffrey N., Chen, Eric Y. H., Chan, Raymond C. K.
Format: Article
Language:English
Subjects:
Chemistry/Food Science
Earth Sciences
Engineering
Forum
Humanities and Social Sciences
Life Sciences
multidisciplinary
Physics
Science
Science (multidisciplinary)
体外
每股收益
症状
神经功能
精神分裂症
精神病
药物治疗
运动障碍
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Summary:Extrapyramidal movement disorders are common in chronic schizophrenia, and may be an intrinsic feature of the illness as well as related to antipsychotic drug treatment. Similar dysfunctions at illness onset may have implications for outcome, and for under standing the mechanisms of illness. The objectives were to examine the clinical correlates of pre-treatment movement disorders at first episode of psychosis, and determine associations with neuropsychological function and striatal structure. Never medicated subjects were recruited from consecutive admissions to Early Psychosis Programs with defined catchment areas in Hong Kong, China, and Halifax, Canada. Standardized clinical, neuropsychological and brain imaging assessments were carried out at baseline and following acute and long term treatment with typical or atypical antipsychotic drugs. At the Hong Kong site, we studied 84 subjects with first episode psychosis （n = 10 with EPS）. At the Halifax site, we studied 40 subjects with first episode psychosis （n = 17 with EPS）, and 23 healthy comparison subiects. Subjects with movement disorders prior to treatment （EPS＋） had higher total
ISSN:1001-6538
1861-9541
DOI:10.1007/s11434-011-4738-y