Beneficial and Detrimental Effects of Glycemic Control on Cardiovascular Disease in Type 2 Diabetes

Epidemiological data demonstrates that improved regulation of blood glucose correlates with better cardiovascular (CV) outcomes. Conversely, some interventional studies have demonstrated that tight glycemic control has no benefit or can even result in worse CV outcomes. These conclusions parallel th...

Full description

Saved in:
Bibliographic Details
Published in:Current cardiology reports 2013-02, Vol.15 (2), p.332, Article 332
Main Authors: Taub, Pam R., Higginbotham, Erin, Henry, Robert R.
Format: Article
Language:English
Subjects:
Blood Glucose - metabolism
Cardiology
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
Diabetes and Cardiovascular Disease (S Malik
Diabetes Mellitus, Type 2 - drug therapy
Glycated Hemoglobin A - metabolism
Humans
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - therapeutic use
Medicine
Medicine & Public Health
Section Editor
Topical Collection on Diabetes and Cardiovascular Disease
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epidemiological data demonstrates that improved regulation of blood glucose correlates with better cardiovascular (CV) outcomes. Conversely, some interventional studies have demonstrated that tight glycemic control has no benefit or can even result in worse CV outcomes. These conclusions parallel the paradox that glycemic control has proven beneficial for microvascular outcomes, while few studies have demonstrated significant macrovascular benefits. This imprecise understanding conveys the need to better comprehend the mechanisms of glycemic control and its impact on CV disease. Such variations in data also require a more comprehensive approach to diabetes and CV disease in which multiple biomarkers such as low density lipoprotein (LDL), low adiponectin, elevated C-reactive protein (CRP) and well established clinical parameters such as high blood pressure, weight, and functional status are incorporated into clinical decision making. Reliance on one parameter in isolation such as glycemic control and one biomarker such as HbA1C does not provide an accurate assessment of CV outcomes.
ISSN:1523-3782
1534-3170
DOI:10.1007/s11886-012-0332-4