Cardiovascular effects of black tea and nicotine alone or in combination against experimental induced heart injury

The present study was designed to elucidate the outcome of subchronic co-administration of black tea and nicotine on cardiovascular performance and whether these substances could modulate the isoproterenol-induced cardiac injury. Animal groups were control, black tea, nicotine and black tea plus nic...

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Bibliographic Details
Published in:Journal of physiology and biochemistry 2012-06, Vol.68 (2), p.271-279
Main Authors: Joukar, Siyavash, Bashiri, Hamideh, Dabiri, Shahriar, Ghotbi, Payam, Sarveazad, Arash, Divsalar, Kouros, Joukar, Farzin, Abbaszadeh, Mahsa
Format: Article
Language:English
Subjects:
Animal Physiology
Biomedical and Life Sciences
Biomedicine
Blood Pressure - drug effects
Camellia sinensis - chemistry
Cardiotonic Agents - pharmacology
Drug Synergism
Drug Therapy, Combination
Heart - drug effects
Heart - physiopathology
Heart Injuries - blood
Heart Injuries - chemically induced
Heart Injuries - drug therapy
Heart Rate - drug effects
Human Physiology
Isoproterenol
Myocardium - pathology
Nicotine - pharmacology
Original Paper
Plant Extracts - pharmacology
Tea
Troponin I - blood
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Summary:The present study was designed to elucidate the outcome of subchronic co-administration of black tea and nicotine on cardiovascular performance and whether these substances could modulate the isoproterenol-induced cardiac injury. Animal groups were control, black tea, nicotine and black tea plus nicotine. Test groups received nicotine (2 mg/kg s.c.) and black tea brewed (p.o.) each alone and in combination for 4 weeks. On the 28th day, myocardial damage was induced by isoproterenol (50 mg/kg i.p.), and blood samples were taken. On day 29, after hemodynamic parameters recording, hearts were removed for histopathological evaluation. Tea or nicotine consumption had no significant effects on hemodynamic indices of animals without heart damage. When the cardiac injury was induced, tea consumption maintained the maximum dp/dt, and nicotine significantly decreased the pressure–rate product. Moreover, severity of heart lesions was lower in the presence of nicotine or black tea. Concomitant use of these materials did not show extra effects on mentioned parameters more than the effect of each of them alone. The results suggest that subchronic administration of black tea or nicotine for a period of 4 weeks may have a mild cardioprotective effect, while concomitant use of these materials cannot intensify this beneficial effect.
ISSN:1138-7548
1877-8755
DOI:10.1007/s13105-011-0141-z