Laparoscopic sleeve gastrectomy leads to rapid improvement of glucose tolerance and insulin secretion with enhanced glucagon-like peptide (GLP-1) secretion

Objective To examine the effect of laparoscopic sleeve gastrectomy (LSG) on glucose metabolism. Methods LSG was performed in two patients with diabetes and one with impaired glucose tolerance. An oral glucose tolerance test (OGTT) was performed preoperatively and 3 months postoperatively. Plasma glu...

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Bibliographic Details
Published in:Diabetology international 2010-12, Vol.1 (2), p.99-103
Main Authors: Ugi, Satoshi, Yamamoto, Hiroshi, Kusunoki, Chisato, Kamo, Azusa, Ikeda, Kazuhiro, Hashimoto, Tetsuya, Nishio, Yoshihiko, Kasama, Kazunori, Tani, Toru, Kashiwagi, Atsunori, Maegawa, Hiroshi
Format: Article
Language:English
Subjects:
Case Report
Diabetes
Endocrinology
Medicine
Medicine & Public Health
Metabolic Diseases
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Summary:Objective To examine the effect of laparoscopic sleeve gastrectomy (LSG) on glucose metabolism. Methods LSG was performed in two patients with diabetes and one with impaired glucose tolerance. An oral glucose tolerance test (OGTT) was performed preoperatively and 3 months postoperatively. Plasma glucose, insulin, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) levels were measured during the OGTT. Fasting ghrelin levels were also measured. Results Two diabetic patients discontinued oral hypoglycemic agents or insulin immediately post-surgery, and the HbA1c level was improved. The area under the curve for insulin and GLP-1 was increased after surgery. In contrast, GIP secretion did not change significantly. Fasting ghrelin levels were decreased in all patients. Conclusions LSG can lead to a rapid improvement of glucose tolerance with enhanced insulin secretion. Increased GLP-1 secretion and decreased ghrelin levels may play a role in improvement of glucose tolerance and insulin secretion after LSG.
ISSN:2190-1678
2190-1686
DOI:10.1007/s13340-010-0011-x