Identification of genes induced by carbamazepine in human bronchial epithelial BEAS-2B cells

Some drugs are limited in their clinical application due to their propensity for inducing adverse side effects. We examined some clinical chemotherapeutic agents that have pulmonary toxic effects. Carbamazepine (CBZ) is an antiepileptic agent and its long-term use is associated with interstitial pne...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology and environmental health sciences 2011-06, Vol.3 (2), p.106-113
Main Authors: Song, Mee, Kim, Youn-Jung, Ryu, Jae-Chun
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Environmental Health
Pharmacology/Toxicology
Research Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Some drugs are limited in their clinical application due to their propensity for inducing adverse side effects. We examined some clinical chemotherapeutic agents that have pulmonary toxic effects. Carbamazepine (CBZ) is an antiepileptic agent and its long-term use is associated with interstitial pneumonia, pulmonary fibrosis, and pulmonary infiltration with eosinophilia. CBZ is persistent in the environment and is frequently detected in water systems. A new technique in toxicity screening, “toxicogenomic technology”, represents a useful approach for evaluating the toxic properties of new drug candidates early in the drug discovery process and their potential effects on the environment. To this end, we have examined gene expression profiles in BEAS-2B cells (a human bronchial epithelial cell line) following exposure to CBZ, which induced pulmonary toxicity, by using a human oligonucleotide chip. We identified 518 up- and 496 down-regulated genes whose expression had changed by more than 1.5-fold ( p
ISSN:2005-9752
DOI:10.1007/s13530-011-0085-2