Steroid Cell Tumour of Ovary in a Post-hysterectomy Woman: A Rare Case Report and Review of Literature

• Published in: Indian journal of gynecologic oncology 2020-03, Vol.18 (1), Article 25
• Main Authors: Gupta, Sabhyata, Kaur, Parvinder, Sachdeva, Ritesh, Chaudhary, Shradha, Batra, Priyanka, Ahluwahlia, Dimple K., Mishra, Buchun, Yadav, Kiran, Sharma, Sarita
• Format: Article
• Language: English
• Subjects: Case Report; Medicine; Medicine & Public Health; Oncology; Surgical Oncology
• ISSN: 2363-8397; 2363-8400
• DOI: 10.1007/s40944-019-0337-7

Steroid cell tumours of the ovary are uncommon sex-hormone-secreting tumours characterized by steroid cell proliferation. The incidence of steroid cell tumour of the ovary is only 0.5% of all ovarian tumours. Here, we present a case of a 59-year-old post-hysterectomy patient who presented with complaints of excessive hair growth, hoarseness of voice and male pattern baldness for 1 year. Transvaginal ultrasonography revealed a well-defined solid 4 × 3 cm hypoechoic lesion, and there was increased heterogeneous vascularity on colour doppler suggestive of neoplastic solid mass lesion of the right ovary. A blood examination showed total serum testosterone of 76 ng/dL, DHEAS—310 ug/dL, and 17-OH progesterone—1025 ng/dL. Her haemoglobin in the preoperative period was 18 gm/dL, though erythropoietin levels were normal. The patient was found positive for JAK2 gene mutation, which is strongly associated with polycythaemia vera. Laparotomy followed by bilateral salpingo-oophorectomy and frozen section was planned. Since frozen section was positive for malignancy in right ovarian mass, omentectomy, bilateral pelvic and para-aortic lymphadenectomy with multiple peritoneal biopsies were performed. The result of histopathology confirmed the diagnosis of steroid cell tumour, probably Leydig cell tumour. A blood examination after a month revealed a marked decline in serum testosterone, i.e. 4.9 ng/dL, DHEAS—15.3 ug/dL, and 17-OH progesterone—0.13 ng/dL.