Prefrontal cortex dysfunction in borna disease virus (BDV)-infected rats

Viruses have been proposed to play a role in the pathogenesis of schizophrenia; however, the mechanisms by which infection could cause the affective, cognitive, and movement disorders of schizophrenia are not understood. The neurotropic RNA virus, Borna disease (BD) virus, linked to schizophrenia by...

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Bibliographic Details
Published in:Biological psychiatry (1969) 1996-10, Vol.40 (7), p.629-636
Main Authors: Solbrig, Marylou V., Koob, George F., Fallon, James H., Reid, Steve, Lipkin, W. Ian
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - metabolism
Adult and adolescent clinical studies
Animals
Autoradiography
Biological and medical sciences
Borna disease
Borna Disease - physiopathology
Borna disease virus - genetics
Brain Mapping
dopamine
Dopamine - physiology
Gene Expression Regulation, Viral - physiology
Male
Medical sciences
Motor Activity - physiology
Neurocognitive Disorders - physiopathology
neurotropic virus
Prefrontal
Prefrontal Cortex - physiopathology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
rat model
Rats
Rats, Inbred Lew
Receptors, Dopamine D1 - physiology
Receptors, Dopamine D2 - physiology
RNA Probes
Schizophrenia
Stereotyped Behavior - physiology
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Summary:Viruses have been proposed to play a role in the pathogenesis of schizophrenia; however, the mechanisms by which infection could cause the affective, cognitive, and movement disorders of schizophrenia are not understood. The neurotropic RNA virus, Borna disease (BD) virus, linked to schizophrenia by serologic studies, causes movement and behavior disorders in a wide variety of mammalian and bird hosts. BD rats have hyperactivity and stereotyped behaviors similar to those that follow neurotoxic or electrolytic lesions in frontal cortex or its catecholamine afferents in rats. BD rats have high levels of viral nucleic acid in the prefrontal cortex (PFC), abnormal mesocortical dopamine activity (elevated levels of DOPAC in PFC), yet no alteration in specific binding of D1 or D2 receptor radioligands in PFC. Since frontal lobe dysfunction is frequently reported in schizophrenia, the BD rat model may provide insights into pathogenesis and management of this debilitating psychiatric disease.
ISSN:0006-3223
1873-2402
DOI:10.1016/0006-3223(95)00480-7