Synthesis and characterization of cyclomaltoheptaose-based metal chelants as probes for intestinal permeability

The syntheses of two cyclomaltoheptaose-based metal chelants, cyclomaltoheptaose-ethylenediaminetetraacetate (CD-EDTA) and cyclomaltoheptaose-diamide-disulfur (CD-DADS), are described. The chelant moieties are attached to the 6-position of a single pyranose in the cyclomaltoheptaose via a short diam...

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Bibliographic Details
Published in:Carbohydrate research 1995-02, Vol.267 (1), p.49-63
Main Authors: Capretta, Alfredo, Maharajh, Rabindranath B., Bell, Russell A.
Format: Article
Language:English
Subjects:
Cyclic disulfide
Cyclomaltoheptaose
Ethylenediaminetetraacetate
Monosubstituted derivatives
β-Cyclodextrin
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Summary:The syntheses of two cyclomaltoheptaose-based metal chelants, cyclomaltoheptaose-ethylenediaminetetraacetate (CD-EDTA) and cyclomaltoheptaose-diamide-disulfur (CD-DADS), are described. The chelant moieties are attached to the 6-position of a single pyranose in the cyclomaltoheptaose via a short diamine spacer chain. Characterization of these novel chelants has been achieved using NMR and MS techniques. The peculiar fluxional properties of the CD-EDTA molecules is also discussed.
ISSN:0008-6215
1873-426X
DOI:10.1016/0008-6215(94)00289-R