Mass spectrometric studies of the metabolites of niaprazine

Niaprazine (NOPRON®) and major urinary metabolites were identified in rat, dog and man by mass spectrometry after a single oral dose of the drug. Metabolism of niaprazine occurred by N-dealkylation, N-dearylation, aromatic hydroxylation and N-oxidation. EI and DCI-NH 3 mass spectra allowed the struc...

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Bibliographic Details
Published in:International journal of mass spectrometry and ion physics 1983, Vol.48, p.93-96
Main Authors: Sanjuan, M., Rovei, V., Dow, J., Benedetti, M.Strolin
Format: Article
Language:English
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Summary:Niaprazine (NOPRON®) and major urinary metabolites were identified in rat, dog and man by mass spectrometry after a single oral dose of the drug. Metabolism of niaprazine occurred by N-dealkylation, N-dearylation, aromatic hydroxylation and N-oxidation. EI and DCI-NH 3 mass spectra allowed the structures of most metabolites to be established. Hydroxylation of niaprazine was proved by formation of BSTFA derivatives. Both aliphatic and aromatic N-oxidation occurred. Aliphatic N-oxides, reduced by SO 2, gave mass spectra characterized by the ions M-16, M-18 and Cope rearrangement; aromatic N-oxides, reduced by TiCl 3 and not by SO 2, gave the ions M-16 and M-17.
ISSN:0020-7381
1873-3034
DOI:10.1016/0020-7381(83)87036-3