Examination of the retention behavior of underivatized profen enantiomers on cyclodextrin silica stationary phases

The separation of the enantiomers of five widely used profen-type non-steroidal anti-inflammatory agents: fenoprofen, flurbiprofen, ibuprofen, ketoprofen and naproxen was studied using four commercially available cyclodextrin silica stationary phases operated in the reversed-phase mode. The retentio...

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Bibliographic Details
Published in:Journal of Chromatography A 1993-03, Vol.634 (2), p.197-204
Main Authors: Beeson, Michelle D., Vigh, Gyula
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Other chromatographic methods
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Summary:The separation of the enantiomers of five widely used profen-type non-steroidal anti-inflammatory agents: fenoprofen, flurbiprofen, ibuprofen, ketoprofen and naproxen was studied using four commercially available cyclodextrin silica stationary phases operated in the reversed-phase mode. The retention behavior of all profens was similar on all the cyclodextrin silica stationary phases studied, but the chiral selectivities differed significantly. Complete separation was achieved for the enantiomers of ibuprofen, flurbiprofen and naproxen.
ISSN:0021-9673
DOI:10.1016/0021-9673(93)83005-D