Gas chromatographic enantiomer separation on a chiral self-associating selector

A novel chiral stationary phase bearing a tripodal selector is described. In gas chromatography this phase exhibits high enantioselectivity towards derivatized amino acids and moderate capability for the enantiomer separation of derivatized hydroxy acids. Due to a C 3 symmetric arrangement of three...

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Bibliographic Details
Published in:Journal of Chromatography A 1996-10, Vol.746 (1), p.53-62
Main Authors: Betschinger, F., Libman, J., Shanzer, A.
Format: Article
Language:English
Subjects:
Amino acids
Chiral stationary phases GC
Enantiomer separation
Hydroxy acids
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Summary:A novel chiral stationary phase bearing a tripodal selector is described. In gas chromatography this phase exhibits high enantioselectivity towards derivatized amino acids and moderate capability for the enantiomer separation of derivatized hydroxy acids. Due to a C 3 symmetric arrangement of three N-acyl-valine- tert.-butyl amide groups the tripodal selector adopts a hydrogen bonding network involving inter- and intrastrand hydrogen bonds. Thus a conformationally constrained structure is formed which is stable up to 150°C.
ISSN:0021-9673
DOI:10.1016/0021-9673(96)00308-1