Stereochemistry of cytidine: conformational analysis and hydrogen bonding

The energy calculations using the INDO molecular orbital method and classical potential function show that the syn conformation of pyrimidine nucleosides having the C (2')-endo or C (2')-endo-C (3')-endo sugar ring puckering is as stable as the corresponding anti form. The O (2')...

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Bibliographic Details
Published in:Journal of molecular structure 1973-01, Vol.17 (1), p.127-142
Main Author: Kang, Sungzong
Format: Article
Language:English
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Summary:The energy calculations using the INDO molecular orbital method and classical potential function show that the syn conformation of pyrimidine nucleosides having the C (2')-endo or C (2')-endo-C (3')-endo sugar ring puckering is as stable as the corresponding anti form. The O (2')-O (2') base-ribose hydrogen bonding significantly alters the Φ CN conformation by confining the allowed Φ CN ranges to about 150–210°.
ISSN:0022-2860
1872-8014
DOI:10.1016/0022-2860(73)85048-3