Influence of methylation of nucleic acid purine bases on their interactions with amino acids through the carboxylic group

Interactions of some adenine and guanine methyl derivatives with the amino acid carboxylic group, in neutral and ionized forms, in anhydrous dimethylsulfoxide have been studied by UV, IR and PMR spectroscopies. It was found that adenine methylation at the N1 and N3 positions reverses the specificity...

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Bibliographic Details
Published in:Journal of molecular structure 1991-10, Vol.250 (1), p.1-11
Main Authors: Kolomiets, Irma N., Kondratyuk, Igor V., Stepanyugin, Andrey V., Samoilenko, Svetlana A., Zheltovsky, Nikolay V.
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods
Nucleic acids
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Summary:Interactions of some adenine and guanine methyl derivatives with the amino acid carboxylic group, in neutral and ionized forms, in anhydrous dimethylsulfoxide have been studied by UV, IR and PMR spectroscopies. It was found that adenine methylation at the N1 and N3 positions reverses the specificity of its interactions with the dissociated and undissociated carboxylic group. It is shown that one amino-group hydrogen atom is sufficient for complex formation of adenine and guanine with the carboxylate ion.
ISSN:0022-2860
1872-8014
DOI:10.1016/0022-2860(91)80118-N