Chiral oximes in asymmetric synthesis. Addition of organometallic reagents to o-(1-phenylethyl) aldoximes

Addition of Grignard and organolithium reagents to O-(1-phcnylethyl) aldoximes in the presence of boron trifluoride etherate gives secondary hydroxylamines in 21–84% yield with up to 95% diastercomeric excess.

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Bibliographic Details
Published in:Tetrahedron 1995-10, Vol.51 (42), p.11473-11488
Main Authors: S. Brown, David, T. Gallagher, Peter, P. Lightfoot, Andrew, J. Moody, Christopher, M.Z. Slawin, Alexandra, Swann, Elizabeth
Format: Article
Language:English
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Description
Summary:Addition of Grignard and organolithium reagents to O-(1-phcnylethyl) aldoximes in the presence of boron trifluoride etherate gives secondary hydroxylamines in 21–84% yield with up to 95% diastercomeric excess.
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(95)00711-G