A new synthetic method for proline diphenyl phosphonates

The diphenyl ester of the phosphonic acid analogue of proline and related dipeptides were prepared by a reaction of the corresponding N-substituted 4-aminobutyraldehyde and triphenyl phosphite. Diastereoisomers were separated and their configuration determined by X-ray crystallography. Diastereoisom...

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Bibliographic Details
Published in:Tetrahedron letters 1995-05, Vol.36 (21), p.3755-3758
Main Authors: Belyaev, Alexander, Borloo, Marianne, Augustyns, Koen, Lambeir, Anne-Marie, De Meester, Ingrid, Scharpe, Simon, Blaton, Norbert, Peeters, Oswald M., De Ranter, Camiel, Haemers, Achiel
Format: Article
Language:English
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Summary:The diphenyl ester of the phosphonic acid analogue of proline and related dipeptides were prepared by a reaction of the corresponding N-substituted 4-aminobutyraldehyde and triphenyl phosphite. Diastereoisomers were separated and their configuration determined by X-ray crystallography. Diastereoisomers of diphenylester of the phosphonic acid analogue of proline derived dipeptides are prepared from 4-aminobutyral-dehyde and triphenyl phosphite. a. Z-Amino acid, b. HCl/THF c. triphenyl phosphite, d. H 2 Pd .
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)00586-2