New enantioselective approach to α-allokainoids by Michael addition to chiral 4-substituted 2,3-didehydroprolinate

(−) and (+) α-Allokainoids hydrochlorides 3 and 4 were obtained by hydrolysis of the corresponding Michael adducts resulting from the addition of diethyl malonate to chiral N-urethane protected ethyl 4-benzyl-2,3-didehydroprolinates 9 and 13 respectively. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 1995-08, Vol.36 (34), p.6149-6152
Main Authors: Ezquerra, Jesús, Escribano, Ana, Rubio, Almudena, Jesús Remuiñán, Modesto, JoséVaquero, Juan
Format: Article
Language:English
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Summary:(−) and (+) α-Allokainoids hydrochlorides 3 and 4 were obtained by hydrolysis of the corresponding Michael adducts resulting from the addition of diethyl malonate to chiral N-urethane protected ethyl 4-benzyl-2,3-didehydroprolinates 9 and 13 respectively. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)01165-E