Taxoids: 11,12-dihydro-4-deacetyldocetaxel

11,12-dihydro-4-deacetyldocetaxel was prepared from 10-deacetylbaccatin III via its reduced derivative at C11, C12. The title compound is not active on microtubules disassembly. The title compound was obtained from 11,12-dihydro-4,10-dideacetylbaccatin III. 11,12-dihydro-4-deacetyldocetaxel was not...

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Bibliographic Details
Published in:Tetrahedron letters 1996-03, Vol.37 (11), p.1777-1780
Main Authors: Marder, Raphaële, Bricard, Laurent, Dubois, Joëlle, Guénard, Daniel, Guéritte-Voegelein, Françoise
Format: Article
Language:English
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Summary:11,12-dihydro-4-deacetyldocetaxel was prepared from 10-deacetylbaccatin III via its reduced derivative at C11, C12. The title compound is not active on microtubules disassembly. The title compound was obtained from 11,12-dihydro-4,10-dideacetylbaccatin III. 11,12-dihydro-4-deacetyldocetaxel was not active on the microtubule disassembly assay.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(96)00117-7