Effects of γ-irradiation on sulphamerazine, sulphadiazine and sulphamethazine

G(-sulphonamide) values obtained for the radiation degradation in nitrogen-saturated solutions range from 2.7–3.2. In nitrous oxide saturated solution G(-sulphonamide) values are 3.4–4.8. Accordingly, both e - aq and HO  radicals contribute to the radiation degradation, with HO  attack predominating...

Full description

Saved in:
Bibliographic Details
Published in:Radiation physics and chemistry 1983, Vol.22 (6), p.989-994
Main Authors: Al-Ali, A.K., Power, D.M.
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
General and physical chemistry
Physical chemistry of induced reactions (with radiations, particles and ultrasonics)
Radiation chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:G(-sulphonamide) values obtained for the radiation degradation in nitrogen-saturated solutions range from 2.7–3.2. In nitrous oxide saturated solution G(-sulphonamide) values are 3.4–4.8. Accordingly, both e - aq and HO  radicals contribute to the radiation degradation, with HO  attack predominating. Attack by e - aq on all three sulphonamides formed sulphanilic acid in different yields. Sulphamerazine degradation resulted in 2-amino-4-methyl pyrimidine formation by scission of the sulphonamide group S- N bond. Similar compounds arose from degradation of sulphadiazine and sulphamethazine. In addition, a phenolic compound was formed during irradiation of the three sulphonamides.
ISSN:0146-5724
DOI:10.1016/0146-5724(83)90165-6