Plasma ACTH levels in depression before and after recovery: Relationship to the dexamethasone suppresion test

Sixteen patients with major depressive disorder who were nonsuppressors on the dexamethasone suppression test (DST) on hospital admission were studied for plasma levels of adrenocorticotropic hormone (ACTH). Eight patients reverted to normal suppression with clinical recovery, while eight remained n...

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Bibliographic Details
Published in:Psychiatry research 1983, Vol.10 (3), p.175-181
Main Authors: Yerevanian, Boghos I., Woolf, Paul D., Iker, Howard P.
Format: Article
Language:English
Subjects:
Adrenocorticotropic hormone (ACTH)
depression
dexamethasone suppression test
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Summary:Sixteen patients with major depressive disorder who were nonsuppressors on the dexamethasone suppression test (DST) on hospital admission were studied for plasma levels of adrenocorticotropic hormone (ACTH). Eight patients reverted to normal suppression with clinical recovery, while eight remained nonsuppressors. There was a significant reduction of ACTH levels in those who continued to be nonsuppressors. The results favored the hypothesis that dexamethasone nonsuppression in depression is mediated by high ACTH levels.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(83)90053-7