Liver function, plasma dexamethasone, and DST results in detoxified alcoholics

Alcohol abuse, alcohol withdrawal, and deterioration of hepatic function have been associated with abnormal dexamethasone suppression test (DST) results. Chronic alcohol abuse may also directly alter the pharmacokinetic disposition of dexamethasone. Plasma dexamethasone concentrations following a DS...

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Bibliographic Details
Published in:Psychiatry research 1989-11, Vol.30 (2), p.217-221
Main Authors: Carson, Stanley W., Halbreich, Uriel, Yeh, Ching-Ming, Galanter, Marc
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Alanine Transaminase - blood
alcoholics
Alcoholism - enzymology
Alcoholism - rehabilitation
Alkaline Phosphatase - blood
Aspartate Aminotransferases - blood
Biological and medical sciences
cortisol
Dexamethasone - pharmacokinetics
Female
Humans
Hydrocortisone - blood
Liver Diseases, Alcoholic - enzymology
liver function
Liver Function Tests
Male
Medical sciences
Middle Aged
Plasma dexamethasone
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Alcohol abuse, alcohol withdrawal, and deterioration of hepatic function have been associated with abnormal dexamethasone suppression test (DST) results. Chronic alcohol abuse may also directly alter the pharmacokinetic disposition of dexamethasone. Plasma dexamethasone concentrations following a DST were determined in 53 detoxified alcoholics. Those with abnormal liver function had higher 4 p.m. plasma dexamethasone concentrations and lower DST cortisol concentrations. Those with normal liver function had lower plasma dexamethasone and higher DST cortisol concentrations consistent with induction of hepatic metabolic enzymes from chronic use of alcohol. The data indicate that liver function is one of the variables influencing dexamethasone disposition and DST cortisol suppression.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(89)90163-7