Treatment of tardive dyskinesia with ceruletide: A double-blind, placebo-controlled study

The effectiveness of a once-weekly i.m. injection of ceruletide (0.8 μg/kg) in suppressing the symptoms of neuroleptic-induced tardive dyskinesia (TD) was evaluated in a double-blind, placebo-controlled, matched-pairs study. Global evaluation of the severity of TD symptoms over the 8-week study peri...

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Bibliographic Details
Published in:Psychiatry research 1992-08, Vol.43 (2), p.129-136
Main Authors: Kojima, Takuya, Yamauchi, Toshio, Miyasaka, Matsue, Koshino, Yoshifumi, Nakane, Yoshibumi, Takahashi, Ryo, Shimazono, Yasuo, Yagi, Gohei
Format: Article
Language:English
Subjects:
abnormal involuntary movements
Adult
Aged
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Ceruletide - adverse effects
Ceruletide - therapeutic use
Double-Blind Method
Dyskinesia, Drug-Induced - drug therapy
Female
Humans
Male
Matched-Pair Analysis
Medical sciences
Middle Aged
Miscellaneous
neuroleptic side effects
Neurologic Examination - drug effects
Neuropharmacology
peptide
Pharmacology. Drug treatments
Schizophrenia
Schizophrenia - drug therapy
Schizophrenic Psychology
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Summary:The effectiveness of a once-weekly i.m. injection of ceruletide (0.8 μg/kg) in suppressing the symptoms of neuroleptic-induced tardive dyskinesia (TD) was evaluated in a double-blind, placebo-controlled, matched-pairs study. Global evaluation of the severity of TD symptoms over the 8-week study period revealed a significant improvement with ceruletide as compared with placebo. Analysis of the therapeutic response to ceruletide over the course of treatment revealed a slow, but long-lasting improvement of TD symptoms. Side effects, which were mild and transient, consisted mainly of nausea and epigastric discomfort. The incidence of side effects did not differ between the ceruletide-and placebo-treated groups. Ceruletide appears to be a novel and practical treatment that can substantially alleviate the symptoms of dyskinesia.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(92)90127-O