Effect of C(5) methylation on self- and heteroassociation of cytidine in aqueous solution

The stacking self-association in aqueous solution of 2′-deoxycytidine and 5-methyl-2′-deoxycytidine has been studied by microcalorimetry; the apparent equilibrium constants and association enthalpy have been determined on the assumption of the isodesmic model of self-association. The relative ioniza...

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Published in:Bioelectrochemistry and Bioenergetics 1986, Vol.16 (3), p.449-454
Main Authors: Soccorsi, Laura, Cotta-Ramusino, Marina, Cignitti, Maurizio, Boccacci, Mario
Format: Article
Language:English
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Summary:The stacking self-association in aqueous solution of 2′-deoxycytidine and 5-methyl-2′-deoxycytidine has been studied by microcalorimetry; the apparent equilibrium constants and association enthalpy have been determined on the assumption of the isodesmic model of self-association. The relative ionization potential of 5-methyl-2′-deoxycytidine has been determined through the analysis of the ultraviolet absorption spectra of its hetero-associate with N-methyl-nicotinamide cation.
ISSN:0302-4598
DOI:10.1016/0302-4598(86)80066-6