A double-blind study to assess the primary irritancy of flurbiprofen (local action transcutaneous) when applied to the skin of Caucasians

A single-centre, double-blind, single-dose study was conducted to assess the primary irritancy of a local action transcutaneous (LAT) patch preparation of flurbiprofen (Targus/TransAct LAT) when applied to the skin of 24 Caucasian volunteers. Comparisons were made of flurbiprofen LAT with non-medica...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 1995-02, Vol.115 (1), p.119-122
Main Authors: Bratty, J.R., Smith, C.M., McEntegart, D.J., Hubbard, A.W.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Caucasian
Drug toxicity and drugs side effects treatment
Local action transcutaneous flurbiprofen
Medical sciences
Pharmacology. Drug treatments
Primary irritancy
Toxicity: skin, dermoskeleton
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A single-centre, double-blind, single-dose study was conducted to assess the primary irritancy of a local action transcutaneous (LAT) patch preparation of flurbiprofen (Targus/TransAct LAT) when applied to the skin of 24 Caucasian volunteers. Comparisons were made of flurbiprofen LAT with non-medicated control, unperfumed moisture cream and a plain lint patch. It was found that the primary irritancy of the flurbiprofen LAT preparation was minimal. This finding, together with previous experience in Japanese subjects, suggests that skin irritancy is unlikely to be a prevalent adverse event when flurbiprofen LAT is used clinically in Caucasian patients.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(94)00304-N