In vitro dissolution of sparingly water-soluble drug dosage forms

An in vitro procedure for the evaluation of sparingly water-soluble drug products has been developed and tested. The data on several sparingly water-soluble drug products, such as danazol capsules, megestrol acetate tablets, prazosin HCl capsules, and quinestrol tablets is presented. The procedure a...

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Bibliographic Details
Published in:International journal of pharmaceutics 1995-10, Vol.125 (1), p.99-106
Main Authors: Shah, Vinod P., Noory, Assad, Noory, Carol, McCullough, Bruce, Clarke, Sanford, Everett, Richard, Naviasky, Helen, Srinivasan, B.N., Fortman, Don, Skelly, Jerome P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
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Summary:An in vitro procedure for the evaluation of sparingly water-soluble drug products has been developed and tested. The data on several sparingly water-soluble drug products, such as danazol capsules, megestrol acetate tablets, prazosin HCl capsules, and quinestrol tablets is presented. The procedure allows a systematic approach to evaluate the dissolution profiles of sparingly water-soluble drug products using various aqueous media including those containing a surfactant such as sodium lauryl sulfate. This approach assists the analyst in developing a sensitive and specific dissolution methodology to characterize the in vitro release pattern of sparingly water-soluble drug products.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(95)00123-Z