Repeated penicillin-induced amygdala epileptic focus in freely moving cats. EEG, polysomnographic (23-h recording), and brain mapping study

The effect of repeated Na-penicillin (PCN) microinjections in the temporal lobe amygdala (AM) of free-moving cats was investigated in order to establish if kindling epileptogenesis is possible with this procedure. The cortical propagation of the PCN-induced post-discharge in AM and the sequence of b...

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Bibliographic Details
Published in:Epilepsy research 1995-10, Vol.22 (2), p.127-136
Main Authors: Fernández-Guardiola, Augusto, Martínez, Adrián, Fernández-Mas, Rodrigo
Format: Article
Language:English
Subjects:
Amygdala
Amygdala - anatomy & histology
Amygdala - physiology
Animals
Behavior, Animal - drug effects
Brain Mapping
Cats
Drug Administration Schedule
EEG
Electroencephalography - drug effects
Epilepsy - chemically induced
Epilepsy - psychology
Kindling
Male
Microinjections
Penicillin
Penicillins - administration & dosage
Penicillins - pharmacology
PGO waves
Polysomnography - drug effects
Sleep
Sleep - drug effects
Sleep - physiology
Topographic mapping
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Summary:The effect of repeated Na-penicillin (PCN) microinjections in the temporal lobe amygdala (AM) of free-moving cats was investigated in order to establish if kindling epileptogenesis is possible with this procedure. The cortical propagation of the PCN-induced post-discharge in AM and the sequence of behavioral changes induced by PCN were similar to those of AM electrical kindling. Nevertheless, the epileptogenic effect of PCN had a different evolution from that of electrical kindling, since some PCN habituation was observed after several doses. Repeated microinjections of PCN did not produce lasting alterations in sleep onset and organization. The only mild changes recorded in the 23 h following PCN microinjections were an increased latency of the first rapid eye movement (REM) sleep episode, a SWS 11 total time and percentage increase, and, with the highest PCN doses, a not very significant diminution of REM sleep total time. Another finding was the occurrence of REM sleep ponto-geniculo-occipital (PGO) waves, coinciding. with a depression of the frequency and amplitude of interictal amygdaloid and cortical spikes. The results showed that a microinjection of PCN in the AM produced a reliable model of interictal spikes, paroxysms and generalized convulsive seizures. Nevertheless, long lasting kindling effect was not observed.
ISSN:0920-1211
1872-6844
DOI:10.1016/0920-1211(95)00037-2