Effects of adenosine uptake inhibitor, dipyridamole, on vagally mediated stimulation of gastric acid secretion in rats

• Published in: Japanese Journal of Pharmacology 1990, Vol.52 (suppl.2), p.107-107
• Main Authors: Tanaka, Toshizo, Morioka, Yuko, Hayashi, Shoryo
• Format: Article
• Language: English
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)32982-8

Theophylline and related compounds (caffeine), which are known to be effective antagonists at adenosine receptors, stimulate the gastric acid secretion in vivo. There is now increasing evidence that exogenous adenosine anologues are involved in the control of gastric function at appropriate concentrations. We examined a hypothesis that adenosine is involved in centrally regulated gastric function in rats. Intracisternally applied dipyridamole (10 μg/rat) inhibited ulcer formation produced by water immersion stress (23℃, 7 hrs) in conscious rats. Intracerebroventricularly applied dipyridamole (3-10 μg/rat) inhibited gastric acid secretion induced by 2-deoxy-D-glucose (200 mg/kg/hr, i.v.) in urethan anesthetized rats. These data suggest that dipyridamole, possibly increasing endogeneous extracellular adenosine levels , significantly reduced stress induced ulcer by central anti-secretory activities.