The effect of fasting on methamphetamine and apomorphine-induced locomotor activities and on the metabolism of brain monoamines in the mouse

• Published in: Japanese Journal of Pharmacology 1988, Vol.46 (suppl), p.173-173
• Main Authors: Itoh, Tadanobu, Kikuchi, Yasushi, Murai, Shigeo, Yoshida, Hiroshi, Masuda, Yoshikatsu, Saito, Hiroko, Nagahama, Hiromichi, Miyate, Hiroki
• Format: Article
• Language: English
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)57361-9

The effects of 24 h fasting on locomotor activity induced by the administration of methamphetamine and apomorphine, on cage-climbing activity and on brain monoamine-related substances were examined in male mice. 1) Increased locomotion induced by methamphetamine (2 mg/kg) was further increased with fasting. Also decreased locomotion induced by a low dose (0.1 mg/kg) of apomorphine was further decreased with fasting. 2) The cage-climbing activity in fasting mice showed the same pattern as that of mice which were fed. 3) In fasting mice, the levels of DA, NE, 5-HT and 5-HIAA in the corpus striatum increased and the level of 3-MT decreased, the level of MHPG in the hypothalamus increased, and level of 3-MT in the nucleus accumbens decreased. These results suggest that fasting may modify the activity of the central dopaminergic, noradrenergic and serotonergic neurons.