High-performance liquid chromatographic separation of enantiomers of 1,1′-binaphthyl-substituted α-aminoisobutyric acid

The direct and indirect stereochemical resolution of the enantiomers of free and N-protected ( R, S)-2′,1′:1,2;1″,2″:3,4-dinaphthcyclohepta-1,3-diene-6-amino-6-carboxylic acid (Bin) was achieved by high-performance liquid chromatographic methods. The direct separation was carried out on a β-cyclodex...

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Bibliographic Details
Published in:Journal of Chromatography A 1997-11, Vol.790 (1), p.41-46
Main Authors: Péter, Antal, Török, Gabriella, Mazaleyrat, Jean-Paul, Wakselman, Michel
Format: Article
Language:English
Subjects:
Aminoisobutyric acid, binaphthyl substituted
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Glycines
Other chromatographic methods
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Summary:The direct and indirect stereochemical resolution of the enantiomers of free and N-protected ( R, S)-2′,1′:1,2;1″,2″:3,4-dinaphthcyclohepta-1,3-diene-6-amino-6-carboxylic acid (Bin) was achieved by high-performance liquid chromatographic methods. The direct separation was carried out on a β-cyclodextrin-based chiral stationary phase, ChiraDex, and the indirect resolution by applying pre-column derivatization with 2,3,4,6-tetra-O-acetyl-β- d-glucopyranosyl isothiocyanate.
ISSN:0021-9673
DOI:10.1016/S0021-9673(97)00750-4