Size stability of phosphatidylcholine-phosphatidylglycerol aerosols and a dynamic film compression state from their interfacial impaction

This study demonstrates the ability of impacting aerosol droplets containing phospholipids to cause a dynamic film compression state at the air-water interface. The humidity dependence of the lipid aerosol particle size distribution is also determined, including hysteresis effects arising from diffe...

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Bibliographic Details
Published in:Journal of colloid and interface science 1985-01, Vol.106 (2), p.547-557
Main Authors: Wojciak, J.F., Notter, R.H., Oberdörster, G.
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
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Summary:This study demonstrates the ability of impacting aerosol droplets containing phospholipids to cause a dynamic film compression state at the air-water interface. The humidity dependence of the lipid aerosol particle size distribution is also determined, including hysteresis effects arising from different directions of humidity change (i.e., humidification vs dehumidification Aerosols were produced by ultrasonic nebulization of surface-active dispersions of dipalmitoyl phosphatidylcholine (DPPC) and egg phosphatidylglycerol (egg-PG) (7:3 molar ratio) in 0.15 M NaCl (1.5 or 10 mg phospholipid/ml Surface activity of aerosols was defined by adsorption measurements and in interfacial deposition studies where a flowing aerosol stream was directed at the surface of a distilled water subphase at 30°C. Continuous deposition of the phospholipid aerosol (linear velocity 150 cm/s) reduced the surface tension of this subphase from 71 dyn/cm to
ISSN:0021-9797
1095-7103
DOI:10.1016/S0021-9797(85)80030-8