Dry-spraying of ascorbic acid or acetaminophen solutions with supercritical carbon dioxide

Carbon dioxide is a very poor solvent for many organic compounds, which makes it a good anti-solvent. When a solution is sprayed into carbon dioxide vapour the anti-solvent reduces the solubility within several tens of milliseconds and the solute precipitates. Two distinct regions can be identified,...

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Bibliographic Details
Published in:Journal of crystal growth 1999-03, Vol.198, p.767-772
Main Authors: Wubbolts, F.E., Bruinsma, O.S.L., van Rosmalen, G.M.
Format: Article
Language:English
Subjects:
Anti-solvent
Dry-spraying
Micronisation
Precipitation
Supercritical
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Summary:Carbon dioxide is a very poor solvent for many organic compounds, which makes it a good anti-solvent. When a solution is sprayed into carbon dioxide vapour the anti-solvent reduces the solubility within several tens of milliseconds and the solute precipitates. Two distinct regions can be identified, below and above the mixture critical pressure. Below this critical pressure the yield remains relatively low and the process is not well controlled. Above the critical pressure small crystals are obtained of about 2 μm with a yield of 90%.
ISSN:0022-0248
1873-5002
DOI:10.1016/S0022-0248(98)01102-6