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Generation of nitroalkanes, hydroximoyl halides and nitrile oxides from the reactions of β-nitrostyrenes with Grignard or organolithium reagents
The β-nitrostyrenes 1 or 2 react with Grignard or organolithium reagents in ether or THF solution to generate by 1,4-addition the intermediate nitronates A. When A is treated with dilute hydrochloric acid, high yields of the nitroalkanes 3 (and oximes 4) or 5 are obtained. Hydroximoyl halides 6, 8 o...
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Published in: | Tetrahedron 1998-01, Vol.54 (5), p.791-822 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The β-nitrostyrenes
1 or
2 react with Grignard or organolithium reagents in ether or THF solution to generate by 1,4-addition the intermediate nitronates
A. When
A is treated with dilute hydrochloric acid, high yields of the nitroalkanes
3 (and oximes
4) or
5 are obtained. Hydroximoyl halides
6, 8 or nitrile oxides
7 can be isolated when the intermediate
A is slowly added to the ice cold concentrated hydrohalic acid. The same products
6 and/or
7 are observed if the nitronates, generated from the substrate
1a, are added to 85% aqueous H
2SO
4 but only the hydrolyzed carboxylic acids
9 are generated when the β-nitrostyrenes
2 are reacted with Grignard reagents and worked up under the same condition. The nitrile oxides
7 can undergo 1,3-dipolar cycloaddition with alkenes or alkynes to generate 2-isoxazolines or isoxazoles. A one-pot synthesis of the [n,3,0] bicyclic (n = 3 or 4) compounds
23–27 by intramolecular nitrile oxide-olefin cycloadditions is reported.
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ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/S0040-4020(97)10356-8 |