Fe(III) mediated oxidative radical cyclisation of cyclopropanone acetals

A variety of cyclopropanone acetal derivatives were found to undergo facile Fe(III) mediated oxidative radical cyclisation to the corresponding trisubstituted cyclopentane esters in good yield and with diastereoselectivities as high as 23:1. A variety of cyclopropanone acetal derivatives were found...

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Bibliographic Details
Published in:Tetrahedron 1998-12, Vol.54 (50), p.15321-15344
Main Authors: Booker-Milburn, Kevin I., Barker, Andy, Brailsford, Wayne, Cox, Brian, Mansley, Tamsin E.
Format: Article
Language:English
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Summary:A variety of cyclopropanone acetal derivatives were found to undergo facile Fe(III) mediated oxidative radical cyclisation to the corresponding trisubstituted cyclopentane esters in good yield and with diastereoselectivities as high as 23:1. A variety of cyclopropanone acetal derivatives were found to undergo facile Fe(III) mediated oxidative radical cyclisation to the corresponding trisubstituted cyclopentane esters in good yield and with diastereoselectivities as high as 23:1.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(98)00958-2