Thermodynamic characterization of the squaramide–carboxylate interaction in squaramide receptors

The thermodynamic characterization of squaramides is described. This fundamental information shows that the association in chloroform or DMSO is mainly exothermic. In contrast, in MeOH the equilibrium is endothermic and is entropically driven. The data shows the influence of a squaramide ring alone,...

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Bibliographic Details
Published in:Tetrahedron letters 2001-07, Vol.42 (29), p.4933-4936
Main Authors: Prohens, Rafel, Rotger, M.Carmen, Piña, M.Neus, Deyà, Pere M, Morey, Jeroni, Ballester, Pablo, Costa, Antoni
Format: Article
Language:English
Subjects:
carboxylate receptors
isothermal titration calorimetry (ITC)
squaramides
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Summary:The thermodynamic characterization of squaramides is described. This fundamental information shows that the association in chloroform or DMSO is mainly exothermic. In contrast, in MeOH the equilibrium is endothermic and is entropically driven. The data shows the influence of a squaramide ring alone, modified or combined with tetraalkylammonium groups as the binding subunit for molecular recognition. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)00880-2