The first asymmetric synthesis of a dopamine D1 agonist, dihydrexidine, employing asymmetric conjugate addition technology

The first asymmetric synthesis of benzophenanthridine dopamine D1 full agonist, dihydrexidine, was accomplished employing three key processes, external chiral ligand-controlled conjugate addition of phenyllithium, Curtius conversion of a carboxylic group to an amino group, and finally Pictet–Spengle...

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Bibliographic Details
Published in:Tetrahedron letters 2001-11, Vol.42 (48), p.8493-8495
Main Authors: Asano, Yasutomi, Yamashita, Mitsuaki, Nagai, Kazushige, Kuriyama, Masami, Yamada, Ken-ichi, Tomioka, Kiyoshi
Format: Article
Language:English
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Summary:The first asymmetric synthesis of benzophenanthridine dopamine D1 full agonist, dihydrexidine, was accomplished employing three key processes, external chiral ligand-controlled conjugate addition of phenyllithium, Curtius conversion of a carboxylic group to an amino group, and finally Pictet–Spengler type cyclization completing skeleton construction. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)01823-8