Addition of some aminoheterocycles to N-benzyl-3-cyanopyridinium chloride

5-Aminopyrazoles react with N-benzyl-3-cyanopyridinium chloride giving 1-benzyl-3-cyano-4-(5-aminopyrazol-4-yl)-1,4-dihydropyridines with high regioselectivity. 5-Aminoisoxazole, 2-aminothiazole and 6-aminouracil react analogously. Graphic

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Bibliographic Details
Published in:Tetrahedron letters 2003-01, Vol.44 (2), p.391-394
Main Authors: Volochnyuk, Dmitriy M, Kostyuk, Alexandr N, Pinchuk, Alexandr M, Tolmachev, Andrei A
Format: Article
Language:English
Subjects:
1,4-dihydropyridine
aminoheterocycles
nucleophilic addition
pyridinium salts
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Summary:5-Aminopyrazoles react with N-benzyl-3-cyanopyridinium chloride giving 1-benzyl-3-cyano-4-(5-aminopyrazol-4-yl)-1,4-dihydropyridines with high regioselectivity. 5-Aminoisoxazole, 2-aminothiazole and 6-aminouracil react analogously. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)02508-X