A novel synthesis of tert-leucine via a Leuckart type reaction

An efficient synthesis of racemic tert-leucine from trimethylpyruvic acid using a Leuckart type reaction is described. A facile resolution of an intermediate with α-methylbenzylamine allows entry into either (R)-or (S)- tert-leucine. An efficient synthesis of racemic tert-leucine from trimethylpyruv...

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Bibliographic Details
Published in:Tetrahedron letters 1997-03, Vol.38 (12), p.2153-2154
Main Authors: Adger, Brian M., Dyer, Ulrich C., Lennon, Ian C., Tiffin, Peter D., Ward, Simon E.
Format: Article
Language:English
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Summary:An efficient synthesis of racemic tert-leucine from trimethylpyruvic acid using a Leuckart type reaction is described. A facile resolution of an intermediate with α-methylbenzylamine allows entry into either (R)-or (S)- tert-leucine. An efficient synthesis of racemic tert-leucine from trimethylpyruvic acid using a Leuckart type reaction is described. A facile resolution of an intermediate with α-MBA allows entry into either (R)- or (S)- tert-leucine.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)00269-4