The Florisil ® catalyzed [1,3]-sigmatropic shift of allyl phenyl ethers — An entryway into novel mycophenolic acid analogues

Florisil ® was found to be effective in promoting the [1,3]-sigmatropic shift of mycophenolic acid related allyl phenyl ethers. Several novel mycophenolic acid analogues were thus prepared. Through a crossover experiment using two deuterated analogues of the model system, the reaction was shown to b...

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Published in:Tetrahedron letters 1997-07, Vol.38 (27), p.4725-4728
Main Authors: Talamás, Francisco X., Smith, David B., Cervantes, Alicia, Franco, Fidencio, Cutler, Serena T., Loughhead, David G., Morgans, David J., Weikert, Robert J.
Format: Article
Language:English
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Summary:Florisil ® was found to be effective in promoting the [1,3]-sigmatropic shift of mycophenolic acid related allyl phenyl ethers. Several novel mycophenolic acid analogues were thus prepared. Through a crossover experiment using two deuterated analogues of the model system, the reaction was shown to be intramolecular. Florisil • was found to be effective in promoting the [1,3]-sigmatropic shift of mycophenolic acid related allyl phenyl ethers.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)00949-0