A novel synthesis of β-trifluoromethyl-substituted isoserine via intramolecular rearrangement of imino ethers

The methodology for the construction of β-trifluoromethyl-substituted isoserine is reported. The fluorinated α-hydroxy-β-imino esters which are the precursors to amino acid derived isoserine were formed firstly via a base catalyzed intramolecular rearrangement of imino ethers, and the subsequent con...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 1998-06, Vol.39 (23), p.4079-4082
Main Authors: Uneyama, Kenji, Hao, Jian, Amii, Hideki
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The methodology for the construction of β-trifluoromethyl-substituted isoserine is reported. The fluorinated α-hydroxy-β-imino esters which are the precursors to amino acid derived isoserine were formed firstly via a base catalyzed intramolecular rearrangement of imino ethers, and the subsequent conversions of these compounds resultedin the formation of the designedisoerines and the related fluorinated compounds. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)00663-7