A mild and effective iodination method using iodine in the presence of bis-(trifluoroacetoxy)iodobenzene

Herein is described a mild and effective iodination method using bis-(trifluoroacetoxy)iodobenzene-iodine as reagent to be applied to electron deficient heterocyclic systems (protected indoles, coumarin…) Moreover, sensitive protecting groups such as acetyl and tert-butyldimethylsilyl were found to...

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Bibliographic Details
Published in:Tetrahedron letters 1998-09, Vol.39 (38), p.6849-6852
Main Authors: Benhida, Rachid, Blanchard, Pierre, Fourrey, Jean-Louis
Format: Article
Language:English
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Summary:Herein is described a mild and effective iodination method using bis-(trifluoroacetoxy)iodobenzene-iodine as reagent to be applied to electron deficient heterocyclic systems (protected indoles, coumarin…) Moreover, sensitive protecting groups such as acetyl and tert-butyldimethylsilyl were found to be stable under the new iodination reaction conditions. In the presence of iodine and bis (trifluoroacetoxy)iodobenzene, sensitive and deactivated substrates were iodinated in high yield.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)01494-4