Synthesis and biological evaluation of fully synthetic bryostatin analogues

The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and...

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Bibliographic Details
Published in:Tetrahedron letters 1998-11, Vol.39 (47), p.8625-8628
Main Authors: Wender, Paul A., De Brabander, Jef, Harran, Patrick G., Hinkle, Kevin W., Lippa, Blaise, Pettit, George R.
Format: Article
Language:English
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Summary:The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and growth inhibitory activities against several human cancer cell lines. The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(98)01955-8