Loading…
Tetrakis(dimethylamino)ethylene (TDAE) as a useful reductant of some chlorodifluoromethylated ketones. A new approach for the synthesis of α,α-difluoroketone derivatives
Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones 1–3. The generated α,α-difluoroacetyl anion was trapped with several aldehydes 4–7, under mild conditions, to give the corresponding 2,2-difluoro-3-hydroxy ketone derivatives 8–13, in mo...
Saved in:
Published in: | Tetrahedron letters 1998-11, Vol.39 (48), p.8853-8856 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones
1–3. The generated α,α-difluoroacetyl anion was trapped with several aldehydes
4–7, under mild conditions, to give the corresponding 2,2-difluoro-3-hydroxy ketone derivatives
8–13, in moderate yields.
Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethyl ketones 1–3. The generated α,α-difluoroacetyl anion was trapped with several aldehydes 4–7, under mild conditions, to give the corresponding 2,2-difluoro-3-hydroxy ketone derivatives 8–13, in moderate yields.
[Display omitted] |
---|---|
ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(98)02028-0 |