Systematic Screening of Chromosome 18 for Loss of Heterozygosity in Esophageal Squamous Cell Carcinoma

Esophageal cancer ranks among the 10 most common cancers in the world, and is almost uniformly fatal. The genetic events leading to the development of esophageal carcinoma are not well established. To identify genomic regions involved in esophageal carcinogenesis, we performed a systematic screening...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1999-05, Vol.111 (1), p.81-86
Main Authors: Karkera, Jayaprakash D, Balan, Kannan V, Yoshikawa, Takeo, Lipman, Timothy O, Korman, Louis, Sharma, Aparna, Patterson, Robert H, Sani, Nirmal, Detera-Wadleigh, Sevilla D, Wadleigh, Robert G
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Carcinoma, Squamous Cell - genetics
Chromosomes, Human, Pair 18
Esophageal Neoplasms - genetics
Esophagus
Gastroenterology. Liver. Pancreas. Abdomen
Genes, Tumor Suppressor
Humans
Loss of Heterozygosity
Medical sciences
Tumors
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Summary:Esophageal cancer ranks among the 10 most common cancers in the world, and is almost uniformly fatal. The genetic events leading to the development of esophageal carcinoma are not well established. To identify genomic regions involved in esophageal carcinogenesis, we performed a systematic screening for loss of heterozygosity (LOH) in 24 samples of squamous cell carcinomas, initially focusing the analysis on chromosome 18. Thirteen short tandem repeat markers spanning 18p and 18q were used. We found a broad peak of LOH spanning 18p11.2 and 18q21.1 with the most frequent LOH (72%) at D18S978 on 18q12.2, which coincides with a known fragile site FRA18A. This region is 4 cM proximal to known tumor suppressor genes and therefore suggests the possible existence of a yet undiscovered tumor suppressor gene.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(98)00225-8