Some practical examples of method validation in the analytical laboratory

Method validation is a key element in both the elaboration of reference methods and the assessment of a laboratory's competence in producing reliable analytical data. Hence, the scope of the term method validation is wide, especially if one bears in mind that there is or at least should be a cl...

Full description

Saved in:
Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 1999-09, Vol.18 (9), p.584-593
Main Authors: van Zoonen, Piet, Hoogerbrugge, Ronald, Gort, Steven M, van de Wiel, Henk J, van 't Klooster, Henk A
Format: Article
Language:English
Subjects:
Calibration
Collaborative trial
Method validation
Quality control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Method validation is a key element in both the elaboration of reference methods and the assessment of a laboratory's competence in producing reliable analytical data. Hence, the scope of the term method validation is wide, especially if one bears in mind that there is or at least should be a close relation between validation, calibration and quality control QA/QC. Moreover, validation should include more than the instrumental step only since the whole cycle from sampling to the final analytical result is important in the assessment of the validity of an analytical result. In this article validation is put in the context of the process of producing chemical information. Two cases are presented in more detail: the development of a European standard for chlorophenols and its validation by a full scale collaborative trial, and the intralaboratory validation of a method for ethylenethiourea using alternative analytical techniques.
ISSN:0165-9936
1879-3142
DOI:10.1016/S0165-9936(99)00159-4