DNA topoisomerases: a new twist for antiparasitic chemotherapy?

The parasitic protozoa are notorious for their bizarre cellular structures and metabolic pathways, a characteristic also true for their nucleic acids. Despite these florid differences from mammalian cells, however, it has proven surprisingly difficult to devise novel chemotherapy against these patho...

Full description

Saved in:
Bibliographic Details
Published in:BBA - Gene Structure and Expression 1998-10, Vol.1400 (1), p.349-354
Main Authors: Nenortas, Elizabeth C., L. Bodley, Annette, Shapiro, Theresa A.
Format: Article
Language:English
Subjects:
Animals
Antiparasitic Agents - pharmacology
DNA Topoisomerases, Type II - genetics
Etoposide - pharmacology
Eukaryota - enzymology
Eukaryota - parasitology
Inhibitor
Malaria
Parasite
Plasmodium falciparum - enzymology
Plasmodium falciparum - parasitology
Protozoon
Topoisomerase
Topoisomerase I Inhibitors
Topoisomerase II Inhibitors
Trypanosoma - enzymology
Trypanosoma - parasitology
Trypanosome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The parasitic protozoa are notorious for their bizarre cellular structures and metabolic pathways, a characteristic also true for their nucleic acids. Despite these florid differences from mammalian cells, however, it has proven surprisingly difficult to devise novel chemotherapy against these pathogens. In recent years, the DNA topoisomerases from parasites have been the focus of considerable study, not only because they are intrinsically interesting, but also because they may provide a target for much-needed new antiparasitic chemotherapy.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/S0167-4781(98)00146-8