Two approaches for irradiating cells individually: a charged-particle microbeam and a soft X-ray microprobe

We are developing two independent, but complementary microbeams for irradiating cells individually in vitro. Firstly, a charged-particle microbeam that uses a fine-bore glass capillary, combined with a transmission detector to precisely irradiate cells with exact numbers of energetic charge-particle...

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Bibliographic Details
Published in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 1997-07, Vol.130 (1), p.270-274
Main Authors: Folkard, Melvyn, Vojnovic, Boris, Schettino, Giuseppe, Forsberg, Mats, Bowey, Graeme, Prise, Kevin M., Michael, Barry D., Michette, Alan G., Pfauntsch, Slawka J.
Format: Article
Language:English
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Summary:We are developing two independent, but complementary microbeams for irradiating cells individually in vitro. Firstly, a charged-particle microbeam that uses a fine-bore glass capillary, combined with a transmission detector to precisely irradiate cells with exact numbers of energetic charge-particles and secondly, a soft X-ray microprobe that produces a very fine beam of carbon-K (278 eV) ultrasoft X-rays, focused to a spot size < 100 nm. X-ray focusing is achieved using zone-plate diffraction lenses developed initially for X-ray microscopy applications.
ISSN:0168-583X
1872-9584
DOI:10.1016/S0168-583X(97)00276-0